Non sedating antihistamine comparison Chat sexs


07-May-2017 06:14

Bilastine does not have any impact on the P450 (CYP) enzyme system of the liver, and there is no evidence of interaction with other drugs except that there is an increased uptake of bilastine when it is taken concomitantly with ketoconazole, erythromycin, or diltiazem [11].

This has been explained by probable interactions with intestinal transporters.

The biological effects of histamine in the allergic reaction are mediated through H1 receptors that coexist in active and inactive forms of g-protein-coupled receptors which balance each other.

Histamine works as an agonist that pushes the balance to the active side leading to effects such as muscular contraction, bronchospasms, upregulation of endothelial permeability, and stimulation of sensory nerves and cough receptors [6].

The affinity for the H1 receptor is 3 and 6 times higher than for cetirizine and fexofenadine, respectively.H1 antihistamines work as inverse agonists that drive the balance toward the inactive side and suppress the effects of histamine.Since these effects are not genuine antagonistic but rather represent a balance displacement between active and inactive forms of H1 receptors, now, the term H1 antihistamine rather than the former “antihistamine antagonist” is used [7].It belongs to the piperidine class of antihistamines as do loratadine, desloratadine, and fexofenadine (Figure 1).

Like other antihistamines bilastine is an H1 receptor inverse agonist.

In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction, bronchospasms, endothelial permeability, and microvascular extravasation [8].



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